Septerna, Inc.: stock overview

SEPNNASDAQHealthcare · Pharmaceutical Preparations

Price

$42.60

November 13, 2026Market cap $2.0B

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  • The full history: 3 fiscal years, from 2023
  • The estimated fair value, with its range and its certainty
  • The full analysis, 18 a month
  • More questions to the chat on its filings
  • Excel with every year
  • An email when it reports, changes its dividend or an officer buys

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In short

Septerna had revenue of $96M over the last 12 months and a net loss of $59M. Revenue grew by 1,644.5% a year on average over the last 2 years. It holds more cash than debt, by $479M. It pays no dividend.

From its SEC filings (latest fiscal year to December 31, 2025) and the price of November 13, 2026.

Its SEC filings
Market cap
$2.0B
47.55M shares
P/E
–
Revenue, 12 months
$96M
+1,644.5% a year over 2 years
Net margin
-61.3%
2025: -106.4%, above 13% of its industry

Worth knowing

What a holder would want to hear from the company's SEC filings of the last three years. Each with its filing, without comment.

3 fiscal years in figures

Each fiscal year's figures as the company filed them, and the share price at its end.

2023–2025 fiscal years

+1,644.5% a year over 2 years

  • 202510-K
    Revenue$46M
  • 202410-K
    Revenue$1.1M
  • 2023
    Revenue$151.0K

Key figures

The company's current figures in five groups. Each term is explained behind its ⓘ.

Valuation

Market cap 
$2.0B
Enterprise value 
$1.5B
P/E 
–
EV / EBIT 
–
EV / Revenue 
16.1
P/B 
4.7
FCF yield 
–
Earnings yield 
–

Profitability

Operating margin 
-76.2%
Net margin 3-year median: -106.4%
-61.3%
ROIC 
-14.8%
ROIC, 5-year average 
-14.7%
ROE 
-15.0%

Growth

Revenue, yearly change 
+4,174.5%
EPS, yearly change 
–
FCF, yearly change 
–
Revenue, average a year 
+1,644.5%

The yearly change compares FY2025 with FY2024.

Balance sheet

Cash 
$479M
Total debt 
$22M
Of which operating leases 
$22M
Net cash 
$479M
Net debt / EBITDA 
–
Interest cover 
–
Current ratio 
4.84

Balance sheet of September 30, 2026.

Returns to shareholders

Dividend yield 
0.00%
Buybacks 
–
Total returned 
0.00%
Shares, yearly change 
+1.0%
Valuation against its own pastEach fiscal year's P/E, P/FCF and P/B beside today's, and the DCF calculator for the company.Valuation

Against its industry

Where its margins and returns stood in fiscal 2025 among the SEC filers of its industry (SIC code 28).

Operating margin

-148.6%

Above 12% of the 285 companies in its industry, and 2% of all.

Net margin

-106.4%

Above 13% of the 302 companies in its industry, and 3% of all.

ROE

-12.8%

Above 41% of the 267 companies in its industry, and 17% of all.

ROA

-8.2%

Above 37% of the 313 companies in its industry, and 16% of all.

From the yearly figures every company files with the SEC, for those with revenue of at least $25 million. The industry is the first two digits of the SIC code.

The company at the SEC

How it is registered and when its fiscal year ends.

Name at the SEC
Septerna, Inc.
CIK
1984086
Exchange
NASDAQ
Industry (SIC)
2834 · Pharmaceutical Preparations
Fiscal year ends
December 31
Latest annual report
December 31, 2025
Reporting currency
USD
Shares
47.55M

Other companies: Healthcare

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The full analysis

What do Septerna's filings show?

These are Septerna's figures. The full Ploutos AI analysis reads everything the company has filed and shows what stands behind it, with a source for every figure.

  • A fair value range built from the filings
  • Earnings quality, debt and red flags
  • Insider and institutional moves
  • The case for and the case against

Questions about SEPN

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What is SEPN's market cap?

Septerna, Inc.'s market cap is $2.0B, at a price of $42.60 on November 13, 2026 and 47.55M shares.

How much revenue does SEPN have?

Septerna had revenue of $96M over the last 12 months. Over the last 2 years it changed by +1,644.5% a year on average.

Does SEPN pay a dividend?

No. Septerna paid no regular dividend over the last 12 months.

Where do the figures come from?

From Septerna, Inc.'s SEC filings (10-K and 10-Q) and the share price. They hold no analyst estimates and no score, and they are not a recommendation.

Related pages

The other pages on US stocks, free to read. On the company pages, the last three fiscal years are open to everyone, five with a free account, and every year with Ploutos Investor.

US stocksThe market today, the sectors, the largest companies and the week's results.The market's sectorsThe 11 sectors side by side: returns, share of the market, median P/E and dividend.Compare stocksTwo companies side by side: price over up to ten years, with and without dividends, and every figure.US dividend stocksEach dividend's yield next to whether the company's cash covers it and whether it was ever cut.

The figures come from the company's SEC filings and the share price, and describe what it has reported. They are not a score or a fair value.