XBI holdings - what the fund actually owns
State Street(R) SPDR(R) S&P(R) Biotech ETF reports 149 stock positions to the SEC, 100% of its assets. The ten largest are 13.3% of the fund, as of Jun 30, 2026.
Each week Ploutos reads the latest N-PORT filing of the largest US equity ETFs. This page is one fund's filing: its reported positions with their weights, where that weight sits by sector, what entered and left since the previous filing, and which other funds hold the most of the same stocks.
Reported positions
149
cover 100% of the fund
Weight of the top 10 holdings
13.3%
of the fund in ten names
Largest position
APGE
1.49% · Apogee Therapeutics Inc
Filing date
Jun 30, 2026
holdings as reported to the SEC
Where the weight sits, by sector
Sectors come from each company's industry code in its SEC record, so they are coarse. 1.8% of the reported weight could not be placed and is shown as unknown.
Full holdings list, heaviest first
| # | Stock | Weight | Cumulative |
|---|---|---|---|
| 1 | APGEApogee Therapeutics Inc | 1.49% | 1.5% |
| 2 | MRNAModerna Inc | 1.41% | 2.9% |
| 3 | TWSTTwist Bioscience Corp | 1.41% | 4.3% |
| 4 | ORKAOruka Therapeutics Inc | 1.38% | 5.7% |
| 5 | KYMRKymera Therapeutics Inc | 1.36% | 7.1% |
| 6 | VKTXViking Therapeutics Inc | 1.30% | 8.4% |
| 7 | PRAXPraxis Precision Medicines Inc | 1.29% | 9.6% |
| 8 | ERASErasca Inc | 1.27% | 10.9% |
| 9 | CGONCG oncology Inc | 1.20% | 12.1% |
| 10 | RVMDRevolution Medicines Inc | 1.20% | 13.3% |
| 11 | RYTMRhythm Pharmaceuticals Inc | 1.20% | 14.5% |
| 12 | PCVXVaxcyte Inc | 1.19% | 15.7% |
| 13 | SLSSELLAS Life Sciences Group Inc | 1.19% | 16.9% |
| 14 | CYTKCytokinetics Inc | 1.18% | 18.1% |
| 15 | DNTHDianthus Therapeutics Inc | 1.18% | 19.2% |
| 16 | MIRMMirum Pharmaceuticals Inc | 1.16% | 20.4% |
| 17 | NTRANatera Inc | 1.16% | 21.6% |
| 18 | ROIVRoivant Sciences Ltd | 1.16% | 22.7% |
| 19 | SRRKScholar Rock Holding Corp | 1.16% | 23.9% |
| 20 | COGTCogent Biosciences Inc | 1.14% | 25.0% |
| 21 | RAREUltragenyx Pharmaceutical Inc | 1.14% | 26.2% |
| 22 | TVTXTravere Therapeutics Inc | 1.13% | 27.3% |
| 23 | ALKSAlkermes PLC | 1.11% | 28.4% |
| 24 | CELCCelcuity Inc | 1.10% | 29.5% |
| 25 | KRYSKrystal Biotech Inc | 1.10% | 30.6% |
| 26 | RLAYRelay Therapeutics Inc | 1.10% | 31.7% |
| 27 | SYRESpyre Therapeutics Inc | 1.10% | 32.8% |
| 28 | TGTXTG Therapeutics Inc | 1.09% | 33.9% |
| 29 | BEAMBeam Therapeutics Inc | 1.08% | 35.0% |
| 30 | INSMInsmed Inc | 1.08% | 36.1% |
| 31 | ARWRArrowhead Pharmaceuticals Inc | 1.07% | 37.1% |
| 32 | PTGXProtagonist Therapeutics Inc | 1.07% | 38.2% |
| 33 | MDGLMadrigal Pharmaceuticals Inc | 1.06% | 39.3% |
| 34 | VERAVera Therapeutics Inc | 1.06% | 40.3% |
| 35 | VRTXVertex Pharmaceuticals Inc | 1.06% | 41.4% |
| 36 | ABBVAbbVie Inc | 1.04% | 42.4% |
| 37 | BIIBBiogen Inc | 1.03% | 43.5% |
| 38 | HALOHalozyme Therapeutics Inc | 1.03% | 44.5% |
| 39 | PTCTPTC Therapeutics Inc | 1.03% | 45.5% |
| 40 | QUREuniQure NV | 1.03% | 46.5% |
| 41 | BBIOBridgebio Pharma Inc | 1.02% | 47.6% |
| 42 | CRSPCRISPR Therapeutics AG | 1.02% | 48.6% |
| 43 | IBRXImmunityBio Inc | 1.02% | 49.6% |
| 44 | SMMTSummit Therapeutics Inc | 1.01% | 50.6% |
| 45 | INCYIncyte Corp | 1.00% | 51.6% |
| 46 | IONSIonis Pharmaceuticals Inc | 1.00% | 52.6% |
| 47 | AMGNAmgen Inc | 0.99% | 53.6% |
| 48 | NBIXNeurocrine Biosciences Inc | 0.97% | 54.6% |
| 49 | ALNYAlnylam Pharmaceuticals Inc | 0.96% | 55.5% |
| 50 | EXELExelixis Inc | 0.96% | 56.5% |
| 51 | GILDGilead Sciences Inc | 0.96% | 57.5% |
| 52 | REGNRegeneron Pharmaceuticals Inc | 0.96% | 58.4% |
| 53 | ACADACADIA Pharmaceuticals Inc | 0.94% | 59.4% |
| 54 | BMRNBioMarin Pharmaceutical Inc | 0.94% | 60.3% |
| 55 | NUVALENT INC | 0.93% | 61.2% |
| 56 | IMVTImmunovant Inc | 0.92% | 62.1% |
| 57 | UTHRUnited Therapeutics Corp | 0.92% | 63.1% |
| 58 | GRALGRAIL Inc | 0.91% | 64.0% |
| 59 | NTLAIntellia Therapeutics Inc | 0.91% | 64.9% |
| 60 | BCRXBioCryst Pharmaceuticals Inc | 0.89% | 65.8% |
| 61 | CATALYST PHARMACEUTICALS INC | 0.87% | 66.6% |
| 62 | DYNDyne Therapeutics Inc | 0.86% | 67.5% |
| 63 | TNGXTango Therapeutics Inc | 0.84% | 68.3% |
| 64 | DNLIDenali Therapeutics Inc | 0.83% | 69.2% |
| 65 | VCYTVeracyte Inc | 0.82% | 70.0% |
| 66 | IDYAIdeaya Biosciences Inc | 0.80% | 70.8% |
| 67 | RXRXRecursion Pharmaceuticals Inc | 0.76% | 71.6% |
| 68 | SRPTSarepta Therapeutics Inc | 0.75% | 72.3% |
| 69 | RCUSArcus Biosciences Inc | 0.74% | 73.0% |
| 70 | SNDXSyndax Pharmaceuticals Inc | 0.72% | 73.8% |
| 71 | ARQTArcutis Biotherapeutics Inc | 0.71% | 74.5% |
| 72 | MLYSMineralys Therapeutics Inc | 0.71% | 75.2% |
| 73 | CLDXCelldex Therapeutics Inc | 0.70% | 75.9% |
| 74 | AGIOAgios Pharmaceuticals Inc | 0.69% | 76.6% |
| 75 | VRDNViridian Therapeutics Inc | 0.67% | 77.2% |
| 76 | NVAXNovavax Inc | 0.66% | 77.9% |
| 77 | IRONDisc Medicine Inc | 0.65% | 78.6% |
| 78 | ADMAADMA Biologics Inc | 0.61% | 79.2% |
| 79 | IMNMImmunome Inc | 0.59% | 79.8% |
| 80 | PVLAPalvella Therapeutics Inc | 0.58% | 80.3% |
| 81 | ABSIAbsci Corp | 0.56% | 80.9% |
| 82 | IOVAIovance Biotherapeutics Inc | 0.56% | 81.5% |
| 83 | NRIXNurix Therapeutics Inc | 0.56% | 82.0% |
| 84 | KODKodiak Sciences Inc | 0.54% | 82.6% |
| 85 | BHVNBiohaven Ltd | 0.53% | 83.1% |
| 86 | ANABAnaptysBio Inc | 0.49% | 83.6% |
| 87 | CAPRCapricor Therapeutics Inc | 0.49% | 84.1% |
| 88 | VCELVericel Corp | 0.49% | 84.6% |
| 89 | GLUEMonte Rosa Therapeutics Inc | 0.48% | 85.0% |
| 90 | STOKStoke Therapeutics Inc | 0.48% | 85.5% |
| 91 | VIRVir Biotechnology Inc | 0.47% | 86.0% |
| 92 | PURRHyperliquid Strategies Inc | 0.46% | 86.4% |
| 93 | CRVSCorvus Pharmaceuticals Inc | 0.41% | 86.9% |
| 94 | TYRATyra Biosciences Inc | 0.41% | 87.3% |
| 95 | CGEMCullinan Therapeutics Inc | 0.40% | 87.7% |
| 96 | PGENPrecigen Inc | 0.38% | 88.0% |
| 97 | ARDXArdelyx Inc | 0.35% | 88.4% |
| 98 | AVTXAvalo Therapeutics Inc | 0.35% | 88.7% |
| 99 | INBXInhibrx Biosciences Inc | 0.35% | 89.1% |
| 100 | TSHATaysha Gene Therapies Inc | 0.35% | 89.4% |
| 101 | MNKDMannKind Corp | 0.34% | 89.8% |
| 102 | ANNXAnnexon Inc | 0.33% | 90.1% |
| 103 | ORICORIC Pharmaceuticals Inc | 0.33% | 90.4% |
| 104 | JBIOJade Biosciences Inc | 0.32% | 90.8% |
| 105 | KURAKura Oncology Inc | 0.32% | 91.1% |
| 106 | OLMAOlema Pharmaceuticals Inc | 0.32% | 91.4% |
| 107 | ZBIOZenas Biopharma Inc | 0.32% | 91.7% |
| 108 | BCAXBicara Therapeutics Inc | 0.30% | 92.0% |
| 109 | CDNACareDx Inc | 0.30% | 92.3% |
| 110 | VORVor BioPharma Inc | 0.30% | 92.6% |
| 111 | XNCRXencor Inc | 0.29% | 92.9% |
| 112 | AVBPArriVent Biopharma Inc | 0.28% | 93.2% |
| 113 | CTMXCytomX Therapeutics Inc | 0.28% | 93.5% |
| 114 | JANXJanux Therapeutics Inc | 0.28% | 93.7% |
| 115 | REPLReplimune Group Inc | 0.28% | 94.0% |
| 116 | SIONSionna Therapeutics Inc | 0.27% | 94.3% |
| 117 | GERNGeron Corp | 0.26% | 94.6% |
| 118 | ALLOAllogene Therapeutics Inc | 0.24% | 94.8% |
| 119 | RIGLRigel Pharmaceuticals Inc | 0.24% | 95.0% |
| 120 | SLDBSolid Biosciences Inc | 0.24% | 95.3% |
| 121 | ALTAltimmune Inc | 0.23% | 95.5% |
| 122 | SANASana Biotechnology Inc | 0.23% | 95.7% |
| 123 | IRWDIronwood Pharmaceuticals Inc | 0.22% | 96.0% |
| 124 | RGNXREGENXBIO Inc | 0.22% | 96.2% |
| 125 | FDMT4D Molecular Therapeutics Inc | 0.20% | 96.4% |
| 126 | IMMXImmix Biopharma Inc | 0.20% | 96.6% |
| 127 | OCGNOcugen Inc | 0.20% | 96.8% |
| 128 | CADLCandel Therapeutics Inc | 0.19% | 97.0% |
| 129 | PRMEPrime Medicine Inc | 0.18% | 97.1% |
| 130 | SVRASavara Inc | 0.18% | 97.3% |
| 131 | DMRADamora Therapeutics Inc | 0.17% | 97.5% |
| 132 | MPLTMapLight Therapeutics Inc | 0.17% | 97.7% |
| 133 | SPRYARS Pharmaceuticals Inc | 0.17% | 97.8% |
| 134 | TRAXFirst Tracks Biotherapeutics Inc | 0.17% | 98.0% |
| 135 | ABUSArbutus Biopharma Corp | 0.16% | 98.2% |
| 136 | MYGNMyriad Genetics Inc | 0.16% | 98.3% |
| 137 | CABACabaletta Bio Inc | 0.15% | 98.5% |
| 138 | CMPXCompass Therapeutics Inc | 0.14% | 98.6% |
| 139 | CATXPerspective Therapeutics Inc | 0.13% | 98.7% |
| 140 | EBSEmergent BioSolutions Inc | 0.13% | 98.9% |
| 141 | PRTAProthena Corp PLC | 0.13% | 99.0% |
| 142 | VNDAVanda Pharmaceuticals Inc | 0.13% | 99.1% |
| 143 | OVIDOvid therapeutics Inc | 0.12% | 99.3% |
| 144 | VSTMVerastem Inc | 0.12% | 99.4% |
| 145 | LXEOLexeo Therapeutics Inc | 0.11% | 99.5% |
| 146 | MDXGMiMedx Group Inc | 0.11% | 99.6% |
| 147 | ACHVAchieve Life Sciences Inc | 0.08% | 99.7% |
| 148 | SGMTSagimet Biosciences Inc | 0.07% | 99.7% |
| 149 | BBOTBridgeBio Oncology Therapeutics Inc | 0.06% | 99.8% |
Funds that hold the most of the same stocks
The share of XBI that is also in each fund, from the positions both report. Open a pair for the full list.
| Fund | Overlap | Shared |
|---|---|---|
| LABUDirexion Daily S&P Biotech Bull 3X Shares | 76.5% | 137 |
| IBBiShares Biotechnology ETF | 41.1% | 121 |
| IWOiShares Russell 2000 Growth ETF | 13.5% | 99 |
| VHTVANGUARD HEALTH CARE INDEX FUND | 13.0% | 120 |
| VBKVANGUARD SMALL-CAP GROWTH INDEX FUND | 10.3% | 43 |
| IYHiShares U.S. Healthcare ETF | 10.2% | 23 |
| ARKGARK Genomic Revolution ETF | 9.8% | 12 |
| IWMiShares Russell 2000 ETF | 9.1% | 121 |
Questions people ask
What are the top holdings of XBI?
Its filing lists 149 stock positions. The largest are APGE 1.5%, MRNA 1.4%, TWST 1.4%, and the ten largest together are 13.3% of the fund. The full list with weights is on this page.
How often do these holdings change?
Funds report their positions to the SEC at each quarter end, and the SEC publishes the filing about 60 days later. Ploutos reads the latest one every week, so the page changes four times a year, and shows the date of the filing it reads.
Why does the coverage not reach 100%?
The list is the stock positions the fund reports. Cash, futures, bonds and other assets the filing carries are not listed, and what the stocks add up to is the coverage shown. A stock fund lands near 100; a fund that holds futures or a cash sleeve lands lower. Weights are of the whole fund.
Compare XBI with another fund·All fund pairs
Descriptive data from public SEC filings. Nothing on this page is a recommendation to buy, sell or hold any fund or stock, and holdings change between filings.